Versican is differentially regulated in the adventitial and medial layers of human vein grafts.

Changes in extracellular matrix proteins may contribute significantly to the adaptation of vein grafts to the arterial circulation. We examined the production and distribution of versican and hyaluronan in intact human vein rings cultured ex vivo, veins perfused ex vivo, and cultured venous adventit...

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Main Authors: Richard D Kenagy, Shinsuke Kikuchi, Steve P Evanko, Matthijs S Ruiter, Marco Piola, Alban Longchamp, Maurizio Pesce, Monica Soncini, Sébastien Deglise, Gianfranco B Fiore, Jacques-Antoine Haefliger, Tannin A Schmidt, Mark W Majesky, Michael Sobel, Thomas N Wight
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0204045