Histone Deacetylase Inhibitors as Anticancer Drugs

Histone Deacetylase Inhibitors as Anticancer Drugs

Carcinogenesis cannot be explained only by genetic alterations, but also involves epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransfer...

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Bibliographic Details
Main Authors: Tomas Eckschlager, Johana Plch, Marie Stiborova, Jan Hrabeta
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:International Journal of Molecular Sciences
Subjects:
histone deacetylases
histone deacetylase inhibitors
cancer
apoptosis
autophagy
cell cycle arrest
anti-angiogenic effect
drug combinations
Online Access:https://www.mdpi.com/1422-0067/18/7/1414

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https://www.mdpi.com/1422-0067/18/7/1414

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