Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. In principle, it should be possible to enhance the activity of insulin by inhibiting its catabolism, which is mediated primarily by insulin-degrading e...

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Bibliographic Details
Main Authors: Malcolm A Leissring, Enrico Malito, Sabrine Hedouin, Lael Reinstatler, Tomoko Sahara, Samer O Abdul-Hay, Shakeel Choudhry, Ghulam M Maharvi, Abdul H Fauq, Malwina Huzarska, Philip S May, Sungwoon Choi, Todd P Logan, Benjamin E Turk, Lewis C Cantley, Marika Manolopoulou, Wei-Jen Tang, Ross L Stein, Gregory D Cuny, Dennis J Selkoe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2866327?pdf=render

Internet

http://europepmc.org/articles/PMC2866327?pdf=render

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