Identification of Two DNMT3A Mutations Compromising Protein Stability and Methylation Capacity in Acute Myeloid Leukemia

Identification of Two DNMT3A Mutations Compromising Protein Stability and Methylation Capacity in Acute Myeloid Leukemia

Somatic mutations of DNMT3A occur in about 20% of acute myeloid leukemia (AML) patients. They mostly consist in heterozygous missense mutations targeting a hotspot site at R882 codon, which exhibit a dominant negative effect and are associated with high myeloblast count, advanced age, and poor progn...

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Main Authors: Samantha Bruno, Maria Teresa Bochicchio, Eugenia Franchini, Antonella Padella, Giovanni Marconi, Andrea Ghelli Luserna di Rorà, Claudia Venturi, Maddalena Raffini, Giovanna Prisinzano, Anna Ferrari, Lorenza Bandini, Valentina Robustelli, Martina Pazzaglia, Maria Chiara Fontana, Chiara Sartor, Maria Chiara Abbenante, Cristina Papayannidis, Simona Soverini, Emanuela Ottaviani, Giorgia Simonetti, Giovanni Martinelli
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2019/5985923

Internet

http://dx.doi.org/10.1155/2019/5985923

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