BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK.

BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK.

BH3 only proteins trigger cell death by interacting with pro- and anti-apoptotic members of the BCL-2 family of proteins. Here we report that BH3 peptides corresponding to the death domain of BH3-only proteins, which bind all the pro-survival BCL-2 family proteins, induce cell death in the absence o...

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Bibliographic Details
Main Authors: Emelyn H Shroff, Colleen M Snyder, G R Scott Budinger, Manu Jain, Teng-Leong Chew, Satya Khuon, Harris Perlman, Navdeep S Chandel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2681411?pdf=render

Internet

http://europepmc.org/articles/PMC2681411?pdf=render

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