Optimized Hepatitis C Virus (HCV) E2 Glycoproteins and their Immunogenicity in Combination with MVA-HCV

Optimized Hepatitis C Virus (HCV) E2 Glycoproteins and their Immunogenicity in Combination with MVA-HCV

Hepatitis C virus (HCV) represents a major global health challenge and an efficient vaccine is urgently needed. Many HCV vaccination strategies employ recombinant versions of the viral E2 glycoprotein. However, recombinant E2 readily forms disulfide-bonded aggregates that might not be optimally suit...

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Bibliographic Details
Main Authors: María Q. Marín, Kwinten Sliepen, Juan García-Arriaza, Sylvie M. Koekkoek, Patricia Pérez, Carlos Óscar S. Sorzano, Carmen E. Gómez, Rogier W. Sanders, Mariano Esteban
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Vaccines
Subjects:
HCV
E2 protein
cysteines
disulfide bonds
MVA
vaccine
Online Access:https://www.mdpi.com/2076-393X/8/3/440

Internet

https://www.mdpi.com/2076-393X/8/3/440

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