Group I p21-activated kinases in leukemia cell adhesion to fibronectin

P21-activated kinases (PAK) regulate processes associated with cytoskeleton dynamics. PAK expression in leukemia cells was measured on protein and mRNA levels. In functional assays, we analyzed the effect of PAK inhibitors IPA-3 and FRAX597 on cell adhesivity and viability. PAK2 was dominant in cell...

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Bibliographic Details
Main Authors: Kateřina Kuželová, Adam Obr, Pavla Röselová, Dana Grebeňová, Petra Otevřelová, Barbora Brodská, Aleš Holoubek
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Cell Adhesion & Migration
Subjects:
pak
aml
irm
Online Access:http://dx.doi.org/10.1080/19336918.2021.1872760