New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment

New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment

New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (<b>7</b>) or aminoalkyl (<b>8</b>) spacers were synthesized as potential multifunctional agents for Alzheimer’s disease (AD)...

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Bibliographic Details
Main Authors: Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Irina I. Faingold, Darya A. Poletaeva, Yuliya V. Soldatova, Raisa A. Kotelnikova, Igor V. Serkov, Anatoly K. Ustinov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Rudy J. Richardson
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
4-amino-2,3-polymethylenequinolines
butylated hydroxytoluene (BHT)
acetylcholinesterase (AChE)
butyrylcholinesterase (BChE)
antioxidants
neuroprotection
Online Access:https://www.mdpi.com/1420-3049/25/24/5891

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https://www.mdpi.com/1420-3049/25/24/5891

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