Treatment and monitoring of Philadelphia chromosome-positive leukemia patients: recent advances and remaining challenges

Treatment and monitoring of Philadelphia chromosome-positive leukemia patients: recent advances and remaining challenges

Abstract The Philadelphia (Ph) chromosome, resulting from the t(9;22)(q34;q11) translocation, can be found in chronic myeloid leukemia (CML) as well as in a subset of acute lymphoblastic leukemias (ALL). The deregulated BCR-ABL1 tyrosine kinase encoded by the fusion gene resulting from the transloca...

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Bibliographic Details
Main Authors: Simona Soverini, Renato Bassan, Thomas Lion
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Hematology & Oncology
Subjects:
Chronic myeloid leukemia
Acute lymphoblastic leukemia
BCR-ABL1
Minimal residual disease
Next-generation sequencing
Tyrosine kinase inhibitors
Online Access:http://link.springer.com/article/10.1186/s13045-019-0729-2

Internet

http://link.springer.com/article/10.1186/s13045-019-0729-2

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