Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model

Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model

The anti-angiogenic soluble fms-like tyrosine kinase 1 (sFLT1) is one of the candidates in the progression of preeclampsia, often associated with fetal growth restriction (FGR). Therapeutic agents against preeclampsia with/without FGR, as well as adequate transgenic sFLT1 mouse models for testing su...

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Bibliographic Details
Main Authors: Rebekka Vogtmann, Elisabeth Kühnel, Nikolai Dicke, Rikst Nynke Verkaik-Schakel, Torsten Plösch, Hubert Schorle, Violeta Stojanovska, Florian Herse, Angela Köninger, Rainer Kimmig, Elke Winterhager, Alexandra Gellhaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Endocrinology
Subjects:
human sFLT1
fetal growth restriction
vascularization
placenta
transgenic mouse model
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00165/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00165/full

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