TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo

by Daniel Nettersheim, Saskia Vadder, Sina Jostes, Alena Heimsoeth, Hubert Schorle
Published 2019-05-01

Persistent Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting in Severely Disrupted Placental Structure and Functionality

by Franziska Kaiser, Julia Hartweg, Selina Jansky, Natalie Pelusi, Caroline Kubaczka, Neha Sharma, Dominik Nitsche, Jan Langkabel, Hubert Schorle
Published 2020-07-01

Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice

by Simon Schneider, Farhad Shakeri, Christian Trötschel, Lena Arévalo, Alexander Kruse, Andreas Buness, Ansgar Poetsch, Klaus Steger, Hubert Schorle
Published 2020-07-01

Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells

by Harald Welter, Carola Herrmann, Thomas Fröhlich, Florian Flenkenthaler, Katja Eubler, Hubert Schorle, Daniel Nettersheim, Artur Mayerhofer, Annette Müller-Taubenberger
Published 2020-11-01

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines

by Stefan Schönberger, Daniela Kraft, Daniel Nettersheim, Hubert Schorle, Anna Casati, Rogerio B. Craveiro, Mahsa Mir Mohseni, Gabriele Calaminus, Dagmar Dilloo
Published 2020-05-01

Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

by Daniel Nettersheim, Lukas C Heukamp, Florian Fronhoffs, Marc J Grewe, Natalie Haas, Anke Waha, Friedemann Honecker, Andreas Waha, Glen Kristiansen, Hubert Schorle
Published 2013-01-01

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma.

by Daniel Nettersheim, Sina Jostes, Rakesh Sharma, Simon Schneider, Andrea Hofmann, Humberto J Ferreira, Per Hoffmann, Glen Kristiansen, Manel B Esteller, Hubert Schorle
Published 2015-07-01

Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice.

by Jana Schemmer, Marcos J Araúzo-Bravo, Natalie Haas, Sabine Schäfer, Susanne N Weber, Astrid Becker, Dawid Eckert, Andreas Zimmer, Daniel Nettersheim, Hubert Schorle
Published 2013-01-01

Correction: Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice

by Jana Schemmer, Marcos J. Araúzo-Bravo, Natalie Haas, Sabine Schäfer, Susanne N. Weber, Astrid Becker, Dawid Eckert, Andreas Zimmer, Daniel Nettersheim, Hubert Schorle
Published 2013-01-01

Correction: Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice.

by Jana Schemmer, Marcos J. Araúzo-Bravo, Natalie Haas, Sabine Schäfer, Susanne N. Weber, Astrid Becker, Dawid Eckert, Andreas Zimmer, Daniel Nettersheim, Hubert Schorle
Published 2013-01-01

Derivation and Maintenance of Murine Trophoblast Stem Cells under Defined Conditions

by Caroline Kubaczka, Claire Senner, Marcos J. Araúzo-Bravo, Neha Sharma, Peter Kuckenberg, Astrid Becker, Andreas Zimmer, Oliver Brüstle, Michael Peitz, Myriam Hemberger, Hubert Schorle
Published 2014-02-01

Reference gene validation for RT-qPCR, a note on different available software packages.

by Ward De Spiegelaere, Jutta Dern-Wieloch, Roswitha Weigel, Valérie Schumacher, Hubert Schorle, Daniel Nettersheim, Martin Bergmann, Ralph Brehm, Sabine Kliesch, Linos Vandekerckhove, Cornelia Fink
Published 2015-01-01

Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia.

by Daniel Holl, Peter Kuckenberg, Tatiana Woynecki, Angela Egert, Astrid Becker, Sebastian Huss, Dirk Stabenow, Andreas Zimmer, Percy Knolle, René Tolba, Hans-Peter Fischer, Hubert Schorle
Published 2011-01-01

Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model

by Rebekka Vogtmann, Elisabeth Kühnel, Nikolai Dicke, Rikst Nynke Verkaik-Schakel, Torsten Plösch, Hubert Schorle, Violeta Stojanovska, Florian Herse, Angela Köninger, Rainer Kimmig, Elke Winterhager, Alexandra Gellhaus
Published 2019-03-01

On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro

by Cornelia Fink, Nelli Baal, Jochen Wilhelm, Poonam Sarode, Roswitha Weigel, Valérie Schumacher, Daniel Nettersheim, Hubert Schorle, Carmen Schröck, Martin Bergmann, Sabine Kliesch, Monika Kressin, Rajkumar Savai
Published 2021-07-01

Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy

by Laura K. Esser, Vittorio Branchi, Sonia Leonardelli, Natalie Pelusi, Adrian G. Simon, Niklas Klümper, Jörg Ellinger, Stefan Hauser, Maria A. Gonzalez-Carmona, Manuel Ritter, Glen Kristiansen, Hubert Schorle, Michael Hölzel, Marieta I. Toma
Published 2020-09-01

TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility

by Lucia A. Torres-Fernández, Jana Emich, Yasmine Port, Sibylle Mitschka, Marius Wöste, Simon Schneider, Daniela Fietz, Daniela Fietz, Manon S. Oud, Sara Di Persio, Nina Neuhaus, Sabine Kliesch, Michael Hölzel, Hubert Schorle, Corinna Friedrich, Frank Tüttelmann, Waldemar Kolanus
Published 2021-05-01