The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures

Accumulating evidence indicates a pivotal role for chronic inflammatory processes in the pathogenesis of neurodegenerative and psychiatric disorders. G protein-coupled formyl peptide receptor 2 (FPR2) mediates pro-inflammatory or anti-/pro-resolving effects upon stimulation with biased agonists. We...

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Bibliographic Details
Main Authors: Ewa Trojan, Kinga Tylek, Monika Leśkiewicz, Władysław Lasoń, Lars-Ove Brandenburg, Marcello Leopoldo, Enza Lacivita, Agnieszka Basta-Kaim
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
MR-39
formyl peptide receptor 2
hippocampal organotypic cultures
lipopolysaccharide
NLPR3 inflammasome
Online Access:https://www.mdpi.com/2073-4409/10/6/1524

Internet

https://www.mdpi.com/2073-4409/10/6/1524

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