Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

Summary: Damage-associated microglia (DAM) profiles observed in Alzheimer’s disease (AD)-related mouse models reflect an activation state that could modulate AD risk or progression. To learn whether human AD microglia (HAM) display a similar profile, we develop a method for purifying cell types from...

Full description

Bibliographic Details
Main Authors: Karpagam Srinivasan, Brad A. Friedman, Ainhoa Etxeberria, Melanie A. Huntley, Marcel P. van der Brug, Oded Foreman, Jonathan S. Paw, Zora Modrusan, Thomas G. Beach, Geidy E. Serrano, David V. Hansen
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
Alzheimer’s disease
microglia
aging
transcriptomics
neurodegenerative diseases
neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472030824X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472030824X

Similar Items