Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

by Karpagam Srinivasan, Brad A. Friedman, Ainhoa Etxeberria, Melanie A. Huntley, Marcel P. van der Brug, Oded Foreman, Jonathan S. Paw, Zora Modrusan, Thomas G. Beach, Geidy E. Serrano, David V. Hansen
Published 2020-06-01

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.

by Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B Kapadia, Lino Gonzalez, Ali A Zarrin, Alison Goate, David V Hansen, Timothy W Behrens, Robert R Graham
Published 2018-11-01

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

by Karpagam Srinivasan, Brad A. Friedman, Jessica L. Larson, Benjamin E. Lauffer, Leonard D. Goldstein, Laurie L. Appling, Jovencio Borneo, Chungkee Poon, Terence Ho, Fang Cai, Pascal Steiner, Marcel P. van der Brug, Zora Modrusan, Joshua S. Kaminker, David V. Hansen
Published 2016-04-01

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

by Brad A. Friedman, Karpagam Srinivasan, Gai Ayalon, William J. Meilandt, Han Lin, Melanie A. Huntley, Yi Cao, Seung-Hye Lee, Patrick C.G. Haddick, Hai Ngu, Zora Modrusan, Jessica L. Larson, Joshua S. Kaminker, Marcel P. van der Brug, David V. Hansen
Published 2018-01-01

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

by Tiffany Wu, Borislav Dejanovic, Vineela D. Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A. Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai H. Barck, Maya Stark, Hai Ngu, Oded Foreman, William J. Meilandt, Justin Elstrott, Michael C. Chang, David V. Hansen, Richard A.D. Carano, Morgan Sheng, Jesse E. Hanson
Published 2019-08-01

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

by Seung-Hye Lee, Claire E. Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A. Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V. Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J. Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalon
Published 2016-08-01