SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA.

SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA.

MITA (also called STING) is a central adaptor protein in innate immune response to cytosolic DNA. Cellular trafficking of MITA from the ER to perinuclear microsomes after DNA virus infection is critical for MITA activation and onset of innate antiviral response. Here we found that SNX8 is a componen...

Full description

Bibliographic Details
Main Authors: Jin Wei, Huan Lian, Wei Guo, Yun-Da Chen, Xia-Nan Zhang, Ru Zang, Li Zhong, Qing Yang, Ming-Ming Hu, Wei-Wei Luo, Hong-Bing Shu, Shu Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6188873?pdf=render

Internet

http://europepmc.org/articles/PMC6188873?pdf=render

Similar Items