Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

by Mi Li, Hong-Bing Shu
Published 2020-05-01

The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

by Heng Lin, Shu Li, Hong-Bing Shu
Published 2019-07-01

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

by Xin Wu, Caoqi Lei, Tian Xia, Xuan Zhong, Qing Yang, Hong-Bing Shu
Published 2019-09-01

ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response.

by Xuan Zhong, Lu Feng, Ru Zang, Cao-Qi Lei, Qing Yang, Hong-Bing Shu
Published 2020-04-01

DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation.

by Tai An, Shu Li, Wei Pan, Po Tien, Bo Zhong, Hong-Bing Shu, Shuwen Wu
Published 2015-09-01

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

by Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu Li
Published 2021-07-01

The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response

by Chen Li, Lu Feng, Wei-Wei Luo, Cao-Qi Lei, Mi Li, Hong-Bing Shu
Published 2021-06-01

PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation.

by Bing-Ru Yan, Lu Zhou, Ming-Ming Hu, Mi Li, Heng Lin, Yan Yang, Yan-Yi Wang, Hong-Bing Shu
Published 2017-09-01

RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.

by Yue Qin, Mao-Tian Zhou, Ming-Ming Hu, Yun-Hong Hu, Jing Zhang, Lin Guo, Bo Zhong, Hong-Bing Shu
Published 2014-09-01

TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

by Hong-Xia Zhang, Zhi-Sheng Xu, Hen Lin, Mi Li, Tian Xia, Kaisa Cui, Su-Yun Wang, Youjun Li, Hong-Bing Shu, Yan-Yi Wang
Published 2018-08-01

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses.

by Qing Yang, Tian-Tian Liu, Heng Lin, Man Zhang, Jin Wei, Wei-Wei Luo, Yun-Hong Hu, Bo Zhong, Ming-Ming Hu, Hong-Bing Shu
Published 2017-09-01

iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA.

by Wei-Wei Luo, Shu Li, Chen Li, Zhou-Qin Zheng, Pan Cao, Zhen Tong, Huan Lian, Su-Yun Wang, Hong-Bing Shu, Yan-Yi Wang
Published 2017-11-01

TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking

by Ming-Shun Sun, Jie Zhang, Li-Qun Jiang, Yi-Xi Pan, Jiao-Yi Tan, Fang Yu, Lin Guo, Lei Yin, Chao Shen, Hong-Bing Shu, Yu Liu
Published 2018-12-01

SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA.

by Jin Wei, Huan Lian, Wei Guo, Yun-Da Chen, Xia-Nan Zhang, Ru Zang, Li Zhong, Qing Yang, Ming-Ming Hu, Wei-Wei Luo, Hong-Bing Shu, Shu Li
Published 2018-10-01

Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

by Zhen Wang, Ji Chen, Chuan Gao, Qiong Xiao, Xi‐Wei Wang, Shan‐Bo Tang, Qing‐Lan Li, Bo Zhong, Zhi‐Yin Song, Hong‐Bing Shu, Lian‐Yun Li, Min Wu
Published 2021-10-01

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

by Xiaona Sun, Ting Liu, Jun Zhao, Hansong Xia, Jun Xie, Yu Guo, Li Zhong, Mi Li, Qing Yang, Cheng Peng, Isabelle Rouvet, Alexandre Belot, Hong-Bing Shu, Pinghui Feng, Junjie Zhang
Published 2020-12-01

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

by Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xia-Nan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming-Ming Hu, Cao-Qi Lei, Wei-Wei Luo, Shu Li, Hong-Bing Shu
Published 2018-08-01

Author Correction: ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

by Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xia-Nan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming-Ming Hu, Cao-Qi Lei, Wei-Wei Luo, Shu Li, Hong-Bing Shu
Published 2021-09-01

USP13 negatively regulates antiviral responses by deubiquitinating STING

by He Sun, Qiang Zhang, Ying-Ying Jing, Man Zhang, Hai-Ying Wang, Zeng Cai, Tianzi Liuyu, Zhi-Dong Zhang, Tian-Chen Xiong, Yan Wu, Qi-Yun Zhu, Jing Yao, Hong-Bing Shu, Dandan Lin, Bo Zhong
Published 2017-05-01