The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models

The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models

Background/Objective: The cardiac Na+/Ca2+ exchanger (NCX) has been identified as a promising target to counter arrhythmia in previous studies investigating the benefit of NCX inhibition. However, the consequences of NCX inhibition have not been investigated in the setting of altered NCX expression...

Full description

Bibliographic Details
Main Authors: Nils Bögeholz, Jan S. Schulte, Sven Kaese, B. Klemens Bauer, Paul Pauls, Dirk G. Dechering, Gerrit Frommeyer, Joshua I. Goldhaber, Uwe Kirchhefer, Lars Eckardt, Christian Pott, Frank U. Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
Na+/Ca2+ exchanger
arrhythmia
heart failure
novel antiarrhythmic strategies
Ca2+ cycling
transgenic mice
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00649/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00649/full

Similar Items