Identification of essential residues for binding and activation in the human 5-HT7(a) receptor by molecular modeling and site-directed mutagenesis

Identification of essential residues for binding and activation in the human 5-HT7(a) receptor by molecular modeling and site-directed mutagenesis

The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders.We examined molecular determinants of ligand binding and G protein activation by the human 5-HT7(a) receptor. The role of several key...

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Bibliographic Details
Main Authors: Agata Antonina Rita eImpellizzeri, Matteo ePappalardo, Livia eBasile, Ornella eManfra, Kjetil Wessel Andressen, Kurt Allen Krobert, Angela eMessina, Finn Olav eLevy, Salvatore eGuccione
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Mutagenesis
G protein
adenylyl cyclase
Docking
Homology Modeling
molecular dynamics
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00092/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00092/full

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