The Impact of Pathway Database Choice on Statistical Enrichment Analysis and Predictive Modeling
Pathway-centric approaches are widely used to interpret and contextualize -omics data. However, databases contain different representations of the same biological pathway, which may lead to different results of statistical enrichment analysis and predictive models in the context of precision medicin...
Main Authors: | Sarah Mubeen, Charles Tapley Hoyt, André Gemünd, Martin Hofmann-Apitius, Holger Fröhlich, Daniel Domingo-Fernández |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-11-01
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Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2019.01203/full |
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