The Impact of Pathway Database Choice on Statistical Enrichment Analysis and Predictive Modeling

Pathway-centric approaches are widely used to interpret and contextualize -omics data. However, databases contain different representations of the same biological pathway, which may lead to different results of statistical enrichment analysis and predictive models in the context of precision medicin...

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Bibliographic Details
Main Authors: Sarah Mubeen, Charles Tapley Hoyt, André Gemünd, Martin Hofmann-Apitius, Holger Fröhlich, Daniel Domingo-Fernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01203/full