Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies

Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies

A library of novel naproxen based 1,3,4-oxadiazole derivatives (<b>8</b>–<b>16</b> and <b>19</b>–<b>26</b>) has been synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized hybrids, compound2-(4-((5-((<i>S</i>)-1...

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Bibliographic Details
Main Authors: Mohammad Mahboob Alam, Syed Nazreen, Abdulraheem S. A. Almalki, Ahmed A. Elhenawy, Nawaf I. Alsenani, Serag Eldin I. Elbehairi, Azizah M. Malebari, Mohammad Y. Alfaifi, Meshari A. Alsharif, Sulaiman Y. M. Alfaifi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceuticals
Subjects:
naproxen
1,3,4-oxadiazole
cytotoxicity
EGFR
computational study
Online Access:https://www.mdpi.com/1424-8247/14/9/870

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https://www.mdpi.com/1424-8247/14/9/870

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