Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity.

Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity.

ASB20123, a C-type natriuretic peptide/ghrelin chimeric peptide, was designed as a novel peptide and demonstrated full agonistic activity for natriuretic-peptide receptor B and a significantly longer half-life in plasma compared with the native peptide. We researched the toxicological profile of ASB...

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Bibliographic Details
Main Authors: Takafumi Yotsumoto, Naomi Morozumi, Ryuichi Nakamura, Toshimasa Jindo, Mayumi Furuya, Yasuyuki Abe, Tomonari Nishimura, Hiroaki Maeda, Hiroyuki Ogasawara, Yoshiharu Minamitake, Kenji Kangawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218229

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https://doi.org/10.1371/journal.pone.0218229

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