Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity.

by Takafumi Yotsumoto, Naomi Morozumi, Ryuichi Nakamura, Toshimasa Jindo, Mayumi Furuya, Yasuyuki Abe, Tomonari Nishimura, Hiroaki Maeda, Hiroyuki Ogasawara, Yoshiharu Minamitake, Kenji Kangawa
Published 2019-01-01

ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism.

by Naomi Morozumi, Takafumi Yotsumoto, Akira Yamaki, Kazunori Yoshikiyo, Sayaka Yoshida, Ryuichi Nakamura, Toshimasa Jindo, Mayumi Furuya, Hiroaki Maeda, Yoshiharu Minamitake, Kenji Kangawa
Published 2019-01-01

Foramen magnum stenosis and midface hypoplasia in C-type natriuretic peptide-deficient rats and restoration by the administration of human C-type natriuretic peptide with 53 amino...

by Takafumi Yotsumoto, Naomi Morozumi, Mayumi Furuya, Toshihito Fujii, Keisho Hirota, Yohei Ueda, Kazumasa Nakao, Shigeki Yamanaka, Kazunori Yoshikiyo, Sayaka Yoshida, Tomonari Nishimura, Yasuyuki Abe, Toshimasa Jindo, Hiroyuki Ogasawara, Akihiro Yasoda
Published 2019-01-01

Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats.

by Keisho Hirota, Mayumi Furuya, Naomi Morozumi, Kazunori Yoshikiyo, Takafumi Yotsumoto, Toshimasa Jindo, Ryuichi Nakamura, Koichiro Murakami, Yohei Ueda, Takeshi Hanada, Hiroko Sade, Sayaka Yoshida, Kei Enomoto, Yugo Kanai, Ichiro Yamauchi, Takafumi Yamashita, Yoriko Ueda-Sakane, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki
Published 2018-01-01

Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death.

by Toshihito Fujii, Keisho Hirota, Akihiro Yasoda, Akiko Takizawa, Naomi Morozumi, Ryuichi Nakamura, Takafumi Yotsumoto, Eri Kondo, Yui Yamashita, Yoriko Sakane, Yugo Kanai, Yohei Ueda, Ichiro Yamauchi, Shigeki Yamanaka, Kazumasa Nakao, Koichiro Kuwahara, Toshimasa Jindo, Mayumi Furuya, Tomoji Mashimo, Nobuya Inagaki, Tadao Serikawa, Kazuwa Nakao
Published 2018-01-01