Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice

Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice

Neurobeachin (NBEA), a brain-enriched multidomain scaffolding protein involved in neurotransmitter release and synaptic functioning, has been identified as a candidate gene for autism spectrum disorder (ASD) in four unrelated patients haploinsufficient for NBEA. The aim of this study was to map the...

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Bibliographic Details
Main Authors: Kim Nuytens, Ilse Gantois, Pieter Stijnen, Emilia Iscru, Annelies Laeremans, Lutgarde Serneels, Lien Van Eylen, Stephen A. Liebhaber, Koen Devriendt, Detlef Balschun, Lutgarde Arckens, John W.M. Creemers, Rudi D'Hooge
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neurobiology of Disease
Subjects:
ASD
BDNF
Behavior
CREB
Neurobeachin
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003671

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http://www.sciencedirect.com/science/article/pii/S0969996112003671

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