Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels

Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels

The sigma 1 receptor (σ1R) and the mu-opioid receptor (MOR) regulate the transient receptor potential (TRP) V1 calcium channel. A series of proteins are involved in the cross-regulation between MORs and calcium channels like the glutamate N-methyl-D-aspartate receptor (NMDAR), including the histidin...

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Bibliographic Details
Main Authors: Elsa Cortés-Montero, Pilar Sánchez-Blázquez, Yara Onetti, Manuel Merlos, Javier Garzón
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
type 1 sigma receptor
transient receptor potential ankyrin member 1
transient receptor potential melastatin member 8
transient receptor potential vanilloid member 1
calmodulin
histidine triad nucleotide-binding protein 1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00634/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00634/full

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