Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer

Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer

Nearly 70% of adults in the US are currently overweight or obese. Despite such high prevalence, the impact of obesity on antitumor immunity and immunotherapy outcomes remains incompletely understood, particularly in patients with breast cancer. Here, we addressed these gaps in knowledge using two mu...

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Bibliographic Details
Main Authors: Justin T. Gibson, Rachael M. Orlandella, William J. Turbitt, Michael Behring, Upender Manne, Robert E. Sorge, Lyse A. Norian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
myeloid-derived suppressor cells (MDSCs)
obesity
immunotherapy resistance
breast cancer
tumor-infiltrating lymphocyte apoptosis
Fas ligand (FasL)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.590794/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.590794/full

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