Diet-Induced Obesity Impairs Outcomes and Induces Multi-Factorial Deficiencies in Effector T Cell Responses Following Anti-CTLA-4 Combinatorial Immunotherapy in Renal Tumor-Bearing...

by William J. Turbitt, Shannon K. Boi, Justin T. Gibson, Rachael M. Orlandella, Lyse A. Norian
Published 2021-05-01

The Antidiabetic Agent Acarbose Improves Anti-PD-1 and Rapamycin Efficacy in Preclinical Renal Cancer

by Rachael M. Orlandella, William J. Turbitt, Justin T. Gibson, Shannon K. Boi, Peng Li, Daniel L. Smith, Lyse A. Norian
Published 2020-10-01

Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer

by Justin T. Gibson, Rachael M. Orlandella, William J. Turbitt, Michael Behring, Upender Manne, Upender Manne, Robert E. Sorge, Robert E. Sorge, Lyse A. Norian, Lyse A. Norian, Lyse A. Norian
Published 2020-10-01

Obesity induces limited changes to systemic and local immune profiles in treatment-naive human clear cell renal cell carcinoma.

by Justin T Gibson, Katlyn E Norris, Gal Wald, Claire M Buchta Rosean, Lewis J Thomas, Shannon K Boi, Laura A Bertrand, Megan Bing, Jennifer B Gordetsky, Jessy Deshane, Peng Li, James A Brown, Kenneth G Nepple, Lyse A Norian
Published 2020-01-01

Obesity diminishes response to PD-1-based immunotherapies in renal cancer

by Peng Li, Amani Makkouk, Jennifer Gordetsky, Eddy Yang, Lewis Thomas, Lakshminarayanan Nandagopal, Hesham Yasin, Rohan Garje, Shannon K Boi, Rachael M Orlandella, Justin Tyler Gibson, William James Turbitt, Gal Wald, Claire Buchta Rosean, Katlyn E Norris, Megan Bing, Laura Bertrand, Brett P Gross, Dmytro Starenki, Kristine I Farag, Robert E Sorge, James A Brown, David M Lubaroff, Rebecca C Arend, Kenneth Nepple, Tatiana T Marquez-Lago, Lyse A Norian
Published 2020-07-01