Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

Transactive response DNA-binding protein 43 (TDP-43) is a major pathological protein in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). There are many disease-associated mutations in TDP-43, and several cellular and animal models with ectopic overexpression of mutant TDP-43 ha...

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Bibliographic Details
Main Authors: Zhijun Zhang, Sandra Almeida, Yubing Lu, Agnes L Nishimura, Lingtao Peng, Danqiong Sun, Bei Wu, Anna M Karydas, Maria C Tartaglia, Jamie C Fong, Bruce L Miller, Robert V Farese, Melissa J Moore, Christopher E Shaw, Fen-Biao Gao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3797144?pdf=render

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http://europepmc.org/articles/PMC3797144?pdf=render

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