Synaptopathy Mechanisms in ALS Caused by C9orf72 Repeat Expansion

by Agnes L. Nishimura, Natalia Arias, Natalia Arias
Published 2021-06-01

The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative Medicine

by Erin C. Hedges, Vera J. Mehler, Agnes L. Nishimura
Published 2016-01-01

Generation of six induced pluripotent stem cell lines from patients with amyotrophic lateral sclerosis with associated genetic mutations in either FUS or ANXA11

by Erin C. Hedges, Simon Topp, Christopher E. Shaw, Agnes L. Nishimura
Published 2021-04-01

Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.

by Agnes L Nishimura, Carole Shum, Emma L Scotter, Amr Abdelgany, Valentina Sardone, Jamie Wright, Youn-Bok Lee, Han-Jou Chen, Bilada Bilican, Monica Carrasco, Tom Maniatis, Siddharthan Chandran, Boris Rogelj, Jean-Marc Gallo, Christopher E Shaw
Published 2014-01-01

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

by Zhijun Zhang, Sandra Almeida, Yubing Lu, Agnes L Nishimura, Lingtao Peng, Danqiong Sun, Bei Wu, Anna M Karydas, Maria C Tartaglia, Jamie C Fong, Bruce L Miller, Robert V Farese, Melissa J Moore, Christopher E Shaw, Fen-Biao Gao
Published 2013-01-01

Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

by Youn-Bok Lee, Han-Jou Chen, João N. Peres, Jorge Gomez-Deza, Jan Attig, Maja Štalekar, Claire Troakes, Agnes L. Nishimura, Emma L. Scotter, Caroline Vance, Yoshitsugu Adachi, Valentina Sardone, Jack W. Miller, Bradley N. Smith, Jean-Marc Gallo, Jernej Ule, Frank Hirth, Boris Rogelj, Corinne Houart, Christopher E. Shaw
Published 2013-12-01

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

by Bhuvaneish T. Selvaraj, Matthew R. Livesey, Chen Zhao, Jenna M. Gregory, Owain T. James, Elaine M. Cleary, Amit K. Chouhan, Angus B. Gane, Emma M. Perkins, Owen Dando, Simon G. Lillico, Youn-Bok Lee, Agnes L. Nishimura, Urjana Poreci, Sai Thankamony, Meryll Pray, Navneet A. Vasistha, Dario Magnani, Shyamanga Borooah, Karen Burr, David Story, Alexander McCampbell, Christopher E. Shaw, Peter C. Kind, Timothy J. Aitman, C. Bruce A. Whitelaw, Ian Wilmut, Colin Smith, Gareth B. Miles, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran
Published 2018-01-01