Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Abstract Background Based on epidemiological and experimental studies, type 2 diabetes mellitus (T2DM), especially insulin resistance that comprises the core mechanism of T2DM, has been recognized as a significant risk factor for Alzheimer’s disease (AD). Studies in humans and diabetic AD model mice...

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Bibliographic Details
Main Authors: Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Aβ
Type 2 diabetes mellitus
Insulin resistance
Dietary intervention
Online Access:http://link.springer.com/article/10.1186/s13024-019-0315-7

Internet

http://link.springer.com/article/10.1186/s13024-019-0315-7

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