The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System

by Tomoki Kuwahara, Takeshi Iwatsubo
Published 2020-03-01

Extracellular α-synuclein levels are regulated by neuronal activity

by Kaoru Yamada, Takeshi Iwatsubo
Published 2018-02-01

Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils.

by Miki Eto, Tadafumi Hashimoto, Takao Shimizu, Takeshi Iwatsubo
Published 2019-01-01

Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.

by Genta Ito, Tetta Fujimoto, Shogo Kamikawaji, Tomoki Kuwahara, Takeshi Iwatsubo
Published 2014-01-01

Facial nerve palsy following the administration of COVID-19 mRNA vaccines: analysis of a self-reporting database

by Kenichiro Sato, Tatsuo Mano, Yoshiki Niimi, Tatsushi Toda, Atsushi Iwata, Takeshi Iwatsubo
Published 2021-10-01

Correction: Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease

by Takuya Tamura, Masaki Sone, Takeshi Iwatsubo, Kazuhiko Tagawa, Erich E. Wanker, Hitoshi Okazawa
Published 2012-01-01

Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease.

by Takuya Tamura, Masaki Sone, Takeshi Iwatsubo, Kazuhiko Tagawa, Erich E Wanker, Hitoshi Okazawa
Published 2011-01-01

Correction: Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease.

by Takuya Tamura, Masaki Sone, Takeshi Iwatsubo, Kazuhiko Tagawa, Erich E. Wanker, Hitoshi Okazawa
Published 2012-01-01

Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheime...

by Toshitaka Ochiai, Toshiharu Sano, Takeru Nagayama, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsubo
Published 2021-11-01

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

by Nobumasa Takasugi, Tomoki Sasaki, Ihori Ebinuma, Satoko Osawa, Hayato Isshiki, Koji Takeo, Taisuke Tomita, Takeshi Iwatsubo
Published 2013-01-01

Seeding Activity-Based Detection Uncovers the Different Release Mechanisms of Seed-Competent Tau Versus Inert Tau via Lysosomal Exocytosis

by Yuki Tanaka, Kaoru Yamada, Kyoko Satake, Itaru Nishida, Matthias Heuberger, Matthias Heuberger, Tomoki Kuwahara, Takeshi Iwatsubo
Published 2019-11-01

Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation

by Tomoki Kuwahara, Kai Funakawa, Tadayuki Komori, Maria Sakurai, Gen Yoshii, Tomoya Eguchi, Mitsunori Fukuda, Takeshi Iwatsubo
Published 2020-11-01

Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies.

by Sangeun Park, Sei-Kyoung Park, Naruaki Watanabe, Tadafumi Hashimoto, Takeshi Iwatsubo, Tatyana A Shelkovnikova, Susan W Liebman
Published 2019-08-01

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques

by Tadafumi Hashimoto, Daisuke Fujii, Yasushi Naka, Mayu Kashiwagi-Hakozaki, Yuko Matsuo, Yusuke Matsuura, Tomoko Wakabayashi, Takeshi Iwatsubo
Published 2020-12-01

Association of active γ-secretase complex with lipid rafts

by Yasuomi Urano, Ikuo Hayashi, Noriko Isoo, Patrick C. Reid, Yoshikazu Shibasaki, Noriko Noguchi, Taisuke Tomita, Takeshi Iwatsubo, Takao Hamakubo, Tatsuhiko Kodama
Published 2005-05-01

Association study of the Ubiquilin gene with Alzheimer's disease

by Faiza Bensemain, Julien Chapuis, Jinzhou Tian, Jing Shi, Uma Thaker, Corinne Lendon, Takeshi Iwatsubo, Philippe Amouyel, David Mann, Jean-Charles Lambert
Published 2006-06-01

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

by Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo
Published 2019-04-01

Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder

by Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo
Published 2019-12-01

Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer's disease by applying methodology from gene co-expression analysis

by Kenichiro Sato, Tatsuo Mano, Hiroshi Matsuda, Michio Senda, Ryoko Ihara, Kazushi Suzuki, Hiroyuki Arai, Kenji Ishii, Kengo Ito, Takeshi Ikeuchi, Ryozo Kuwano, Tatsushi Toda, Takeshi Iwatsubo, Atsushi Iwata
Published 2019-01-01

Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

by Kiwami Kidana, Takuya Tatebe, Kaori Ito, Norikazu Hara, Akiyoshi Kakita, Takashi Saito, Sho Takatori, Yasuyoshi Ouchi, Takeshi Ikeuchi, Mitsuhiro Makino, Takaomi C Saido, Masahiro Akishita, Takeshi Iwatsubo, Yukiko Hori, Taisuke Tomita
Published 2018-03-01