The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

Epithelial cells that lose attachment to the extracellular matrix undergo a specialized form of apoptosis called anoikis. Here, using large-scale RNA interference (RNAi) screening, we find that KDM3A, a histone H3 lysine 9 (H3K9) mono- and di-demethylase, plays a pivotal role in anoikis induction. I...

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Bibliographic Details
Main Authors: Victoria E Pedanou, Stéphane Gobeil, Sébastien Tabariès, Tessa M Simone, Lihua Julie Zhu, Peter M Siegel, Michael R Green
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
anoikis
BNIP3
BNIP3L
KDM3A
histone demethylase
Online Access:https://elifesciences.org/articles/16844

Internet

https://elifesciences.org/articles/16844

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