A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair

A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair

Antibodies that block the Wnt inhibitors sclerostin and DKK- 1 enhance bone formation and fracture repair. Here the authors show these monospecific antibodies induce compensatory mechanisms that limit efficacy, and have designed a sclerostin/DKK-1 bispecific antibody that promotes superior fracture...

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Bibliographic Details
Main Authors: Monica Florio, Kannan Gunasekaran, Marina Stolina, Xiaodong Li, Ling Liu, Barbara Tipton, Hossein Salimi-Moosavi, Franklin J. Asuncion, Chaoyang Li, Banghua Sun, Hong Lin Tan, Li Zhang, Chun-Ya Han, Ryan Case, Amy N. Duguay, Mario Grisanti, Jennitte Stevens, James K. Pretorius, Efrain Pacheco, Heidi Jones, Qing Chen, Brian D. Soriano, Jie Wen, Brenda Heron, Frederick W. Jacobsen, Emil Brisan, William G. Richards, Hua Zhu Ke, Michael S. Ominsky
Format: Article
Language:English
Published: Nature Publishing Group 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11505

Internet

https://doi.org/10.1038/ncomms11505

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