<i>IRF2BP2</i> Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

<i>IRF2BP2</i> Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

Interferon regulatory factor 2 binding protein 2 (IRF2BP2) is a transcriptional coregulator that has an important role in the regulation of the immune response. IRF2BP2 has been associated with the Janus kinase (JAK)—signal transducers and activators of transcription (STAT) pathway, but its exact ro...

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Bibliographic Details
Main Authors: Maaria Palmroth, Hanna Viskari, Mikko R. J. Seppänen, Salla Keskitalo, Anniina Virtanen, Markku Varjosalo, Olli Silvennoinen, Pia Isomäki
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceuticals
Subjects:
interferon regulatory factor-2 binding protein-2 (IRF2BP2)
JAK–STAT pathway
interferons
inflammation
Online Access:https://www.mdpi.com/1424-8247/14/8/797

Internet

https://www.mdpi.com/1424-8247/14/8/797

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