Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.

Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.

Statin therapy reduces the risk of coronary heart disease (CHD), however, the person-to-person variability in response to statin therapy is not well understood. We have investigated the effect of genetic variation on the reduction of CHD events by pravastatin. First, we conducted a genome-wide assoc...

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Bibliographic Details
Main Authors: Dov Shiffman, Stella Trompet, Judy Z Louie, Charles M Rowland, Joseph J Catanese, Olga A Iakoubova, Todd G Kirchgessner, Rudi G J Westendorp, Anton J M de Craen, P Eline Slagboom, Brendan M Buckley, David J Stott, Naveed Sattar, James J Devlin, Christopher J Packard, Ian Ford, Frank M Sacks, J Wouter Jukema
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3364212?pdf=render

Internet

http://europepmc.org/articles/PMC3364212?pdf=render

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