Specific Induction of Double Negative B Cells During Protective and Pathogenic Immune Responses

Specific Induction of Double Negative B Cells During Protective and Pathogenic Immune Responses

Double negative (DN) (CD19+CD20lowCD27-IgD-) B cells are expanded in patients with autoimmune and infectious diseases; however their role in the humoral immune response remains unclear. Using systematic flow cytometric analyses of peripheral blood B cell subsets, we observed an inflated DN B cell po...

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Bibliographic Details
Main Authors: Christoph Ruschil, Gisela Gabernet, Gildas Lepennetier, Simon Heumos, Miriam Kaminski, Zsuzsanna Hracsko, Martin Irmler, Johannes Beckers, Ulf Ziemann, Sven Nahnsen, Gregory P. Owens, Jeffrey L. Bennett, Bernhard Hemmer, Markus C. Kowarik
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
influenza vaccination
TBE vaccination
vaccination
B cells
double negative B cells
neuromyelitis optica spectrum disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.606338/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.606338/full

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