Functional analysis of sites within PCSK9 responsible for hypercholesterolemias⃞

Functional analysis of sites within PCSK9 responsible for hypercholesterolemias⃞

Mutations within proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with dominant forms of familial hypercholesterolemia. PCSK9 binds the LDL receptor (LDLR), and addition of PCSK9 to cells promotes degradation of LDLR. PCSK9 mutant proteins associated with hypercholesterolemia (S1...

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Bibliographic Details
Main Authors: Shilpa Pandit, Doug Wisniewski, Joseph C. Santoro, Sookhee Ha, Vijayalakshmi Ramakrishnan, Rose M. Cubbon, Richard T. Cummings, Samuel D. Wright, Carl P. Sparrow, Ayesha Sitlani, Timothy S. Fisher
Format: Article
Language:English
Published: Elsevier 2008-06-01
Series:Journal of Lipid Research
Subjects:
proprotein convertase subtilisin/kexin type 9
LDL
LDL receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520423776

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http://www.sciencedirect.com/science/article/pii/S0022227520423776

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