Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice

by Elena Fattori, Manuela Cappelletti, Paola Lo Surdo, Alessandra Calzetta, Claus Bendtsen, Yan G. Ni, Shilpa Pandit, Ayesha Sitlani, Giuseppe Mesiti, Andrea Carfí, Paolo Monaci
Published 2012-08-01

Functional analysis of sites within PCSK9 responsible for hypercholesterolemias⃞

by Shilpa Pandit, Doug Wisniewski, Joseph C. Santoro, Sookhee Ha, Vijayalakshmi Ramakrishnan, Rose M. Cubbon, Richard T. Cummings, Samuel D. Wright, Carl P. Sparrow, Ayesha Sitlani, Timothy S. Fisher
Published 2008-06-01

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

by Mali Liu, Guoxin Wu, Jennifer Baysarowich, Michael Kavana, George H. Addona, Kathleen K. Bierilo, John S. Mudgett, Guillaume Pavlovic, Ayesha Sitlani, John J. Renger, Brian K. Hubbard, Timothy S. Fisher, Celina V. Zerbinatti
Published 2010-09-01

Biochemical characterization of cholesteryl ester transfer protein inhibitors

by Mollie Ranalletta, Kathleen K. Bierilo, Ying Chen, Denise Milot, Qing Chen, Elaine Tung, Caroline Houde, Nadine H. Elowe, Margarita Garcia-Calvo, Gene Porter, Suzanne Eveland, Betsy Frantz-Wattley, Mike Kavana, George Addona, Peter Sinclair, Carl Sparrow, Edward A. O'Neill, Ken S. Koblan, Ayesha Sitlani, Brian Hubbard, Timothy S. Fisher
Published 2010-09-01

Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis[S]

by Alison M. Strack, Ester Carballo-Jane, Sheng-ping Wang, Jiyan Xue, Xiaoli Ping, Lesley Ann McNamara, Anil Thankappan, Olga Price, Michael Wolff, T.J. Wu, Douglas Kawka, Michele Mariano, Charlotte Burton, Ching H. Chang, Jing Chen, John Menke, Silvi Luell, Emanuel I. Zycband, Xinchun Tong, Richard Raubertas, Carl P. Sparrow, Brian Hubbard, John Woods, Gary O'Neill, M. Gerard Waters, Ayesha Sitlani
Published 2013-01-01

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S]

by Yan G. Ni, Stefania Di Marco, Jon H. Condra, Laurence B. Peterson, Weirong Wang, Fubao Wang, Shilpa Pandit, Holly A. Hammond, Ray Rosa, Richard T. Cummings, Dana D. Wood, Xiaomei Liu, Matthew J. Bottomley, Xun Shen, Rose M. Cubbon, Sheng-ping Wang, Douglas G. Johns, Cinzia Volpari, Lora Hamuro, Jayne Chin, Lingyi Huang, Jing Zhang Zhao, Salvatore Vitelli, Peter Haytko, Douglas Wisniewski, Lyndon J. Mitnaul, Carl P. Sparrow, Brian Hubbard, Andrea Carfí, Ayesha Sitlani
Published 2011-01-01