Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients.

Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients.

Norwalk virus and human papilloma virus, two viruses that infect humans at mucosal surfaces, have been found capable of rapidly penetrating human mucus secretions. Viral vectors for gene therapy of Cystic Fibrosis (CF) must similarly penetrate purulent lung airway mucus (sputum) to deliver DNA to ai...

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Bibliographic Details
Main Authors: Kaoru Hida, Samuel K Lai, Jung Soo Suk, Sang Y Won, Michael P Boyle, Justin Hanes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3103503?pdf=render

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http://europepmc.org/articles/PMC3103503?pdf=render

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