Altering mucus rheology to "solidify" human mucus at the nanoscale.

by Samuel K Lai, Ying-Ying Wang, Richard Cone, Denis Wirtz, Justin Hanes
Published 2009-01-01

Mucoadhesive nanoparticles may disrupt the protective human mucus barrier by altering its microstructure.

by Ying-Ying Wang, Samuel K Lai, Conan So, Craig Schneider, Richard Cone, Justin Hanes
Published 2011-01-01

Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients.

by Kaoru Hida, Samuel K Lai, Jung Soo Suk, Sang Y Won, Michael P Boyle, Justin Hanes
Published 2011-01-01

Ultra‐thin, high strength, antibiotic‐eluting sutures for prevention of ophthalmic infection

by Kunal S. Parikh, Revaz Omiadze, Aditya Josyula, Richard Shi, Nicole M. Anders, Ping He, Youseph Yazdi, Peter J. McDonnell, Laura M. Ensign, Justin Hanes
Published 2021-05-01

Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis

by Elga Bandeira, Helena Oliveira, Johnatas D. Silva, Rubem F. S. Menna-Barreto, Christina M. Takyia, Jung S. Suk, Kenneth W. Witwer, Michael E. Paulaitis, Justin Hanes, Patricia R. M. Rocco, Marcelo M. Morales
Published 2018-05-01

An ion‐paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection

by Aditya Josyula, Revaz Omiadze, Kunal Parikh, Pranjali Kanvinde, Matthew B. Appell, Pratikkumar Patel, Hiwa Saeed, Yogesh Sutar, Nicole Anders, Ping He, Peter J. McDonnell, Justin Hanes, Abhijit A. Date, Laura M. Ensign
Published 2021-09-01

The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis.

by Thuy Hoang, Emily Toler, Kevin DeLong, Nomfuneko A Mafunda, Seth M Bloom, Hannah C Zierden, Thomas R Moench, Jenell S Coleman, Justin Hanes, Douglas S Kwon, Samuel K Lai, Richard A Cone, Laura M Ensign
Published 2020-01-01

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy

by Gregg A. Duncan, Namho Kim, Yanerys Colon-Cortes, Jason Rodriguez, Marina Mazur, Susan E. Birket, Steven M. Rowe, Natalie E. West, Alessandra Livraghi-Butrico, Richard C. Boucher, Justin Hanes, George Aslanidi, Jung Soo Suk
Published 2018-06-01

Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles

by Hiroki Tsujinaka, Jie Fu, Jikui Shen, Yun Yu, Zibran Hafiz, Joshua Kays, David McKenzie, Delia Cardona, David Culp, Ward Peterson, Brian C. Gilger, Christopher S. Crean, Jin-Zhong Zhang, Yogita Kanan, Weiling Yu, Jeffrey L. Cleland, Ming Yang, Justin Hanes, Peter A. Campochiaro
Published 2020-02-01

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

by Jong-Sung Park, Yumin Oh, Yong Joo Park, Ogyi Park, Hoseong Yang, Stephanie Slania, Laura K. Hummers, Ami A. Shah, Hyoung-Tae An, Jiyeon Jang, Maureen R. Horton, Joseph Shin, Harry C. Dietz, Eric Song, Dong Hee Na, Eun Ji Park, Kwangmeyung Kim, Kang Choon Lee, Viktor V. Roschke, Justin Hanes, Martin G. Pomper, Seulki Lee
Published 2019-03-01

Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

by Liyun Zhang, Conan Chen, Jie Fu, Brendan Lilley, Cynthia Berlinicke, Baranda Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy Mulligan, Kevin Emmerich, Meera T Saxena, Kelsi R Hall, Abigail V Sharrock, Carlene Brandon, Hyejin Park, Tae-In Kam, Valina L Dawson, Ted M Dawson, Joong Sup Shim, Justin Hanes, Hongkai Ji, Jun O Liu, Jiang Qian, David F Ackerley, Baerbel Rohrer, Donald J Zack, Jeff S Mumm
Published 2021-06-01

Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

by Henry T. Hsueh, Yoo-Chun Kim, Ian Pitha, Matthew D. Shin, Cynthia A. Berlinicke, Renee Ti Chou, Elizabeth Kimball, Julie Schaub, Sarah Quillen, Kirby T. Leo, Hyounkoo Han, Amy Xiao, Youngwook Kim, Matthew Appell, Usha Rai, HyeYoung Kwon, Patricia Kolodziejski, Laolu Ogunnaike, Nicole M. Anders, Avelina Hemingway, Joan L. Jefferys, Abhijit A. Date, Charles Eberhart, Thomas V. Johnson, Harry A. Quigley, Donald J. Zack, Justin Hanes, Laura M. Ensign
Published 2021-05-01