Infectious prions accumulate to high levels in non proliferative C2C12 myotubes.

Infectious prions accumulate to high levels in non proliferative C2C12 myotubes.

Prion diseases are driven by the strain-specific, template-dependent transconformation of the normal cellular prion protein (PrP(C)) into a disease specific isoform PrP(Sc). Cell culture models of prion infection generally use replicating cells resulting in lower levels of prion accumulation compare...

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Bibliographic Details
Main Authors: Allen Herbst, Pamela Banser, Camilo Duque Velasquez, Charles E Mays, Valerie L Sim, David Westaway, Judd M Aiken, Debbie McKenzie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3820720?pdf=render

Internet

http://europepmc.org/articles/PMC3820720?pdf=render

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