Prion propagation in vitro: are we there yet?

by Chongsuk Ryou, Charles E. Mays
Published 2008-01-01

Infectious prions accumulate to high levels in non proliferative C2C12 myotubes.

by Allen Herbst, Pamela Banser, Camilo Duque Velasquez, Charles E Mays, Valerie L Sim, David Westaway, Judd M Aiken, Debbie McKenzie
Published 2013-01-01

In vitro amplification of misfolded prion protein using lysate of cultured cells.

by Charles E Mays, Jihyun Yeom, Hae-Eun Kang, Jifeng Bian, Vadim Khaychuk, Younghwan Kim, Jason C Bartz, Glenn C Telling, Chongsuk Ryou
Published 2011-01-01

Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.

by David Westaway, Sacha Genovesi, Nathalie Daude, Rebecca Brown, Agnes Lau, Inyoul Lee, Charles E Mays, Janaky Coomaraswamy, Brenda Canine, Rose Pitstick, Allen Herbst, Jing Yang, Kerry W S Ko, Gerold Schmitt-Ulms, Stephen J Dearmond, Debbie McKenzie, Leroy Hood, George A Carlson
Published 2011-11-01

A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alle...

by Robert C C Mercer, Nathalie Daude, Lyudmyla Dorosh, Ze-Lin Fu, Charles E Mays, Hristina Gapeshina, Serene L Wohlgemuth, Claudia Y Acevedo-Morantes, Jing Yang, Neil R Cashman, Michael B Coulthart, Dawn M Pearson, Jeffrey T Joseph, Holger Wille, Jiri G Safar, Gerard H Jansen, Maria Stepanova, Brian D Sykes, David Westaway
Published 2018-01-01