Precise assembly of complex beta sheet topologies from de novo designed building blocks

Precise assembly of complex beta sheet topologies from de novo designed building blocks

Design of complex alpha-beta protein topologies poses a challenge because of the large number of alternative packing arrangements. A similar challenge presumably limited the emergence of large and complex protein topologies in evolution. Here, we demonstrate that protein topologies with six and seve...

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Bibliographic Details
Main Authors: Indigo Chris King, James Gleixner, Lindsey Doyle, Alexandre Kuzin, John F Hunt, Rong Xiao, Gaetano T Montelione, Barry L Stoddard, Frank DiMaio, David Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
protein design
protein folding
beta sheets
Online Access:https://elifesciences.org/articles/11012

Internet

https://elifesciences.org/articles/11012

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