NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.

NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.

Nuclear factor (NF)-κB inducing kinase (NIK) is a central player in the non-canonical NF κB pathway, which phosphorylates IκB kinase α (IKKα) resulting in enhancement of target gene expression. We have recently shown that IKKα responds to a variety of stimuli including oxidants and cigarette smoke (...

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Bibliographic Details
Main Authors: Sangwoon Chung, Isaac K Sundar, Jae-Woong Hwang, Fiona E Yull, Timothy S Blackwell, Vuokko L Kinnula, Michael Bulger, Hongwei Yao, Irfan Rahman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3160853?pdf=render

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http://europepmc.org/articles/PMC3160853?pdf=render

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