IL15RA and SMAD3 Genetic Variants Predict Overall Survival in Metastatic Colorectal Cancer Patients Treated with FOLFIRI Therapy: A New Paradigm

IL15RA and SMAD3 Genetic Variants Predict Overall Survival in Metastatic Colorectal Cancer Patients Treated with FOLFIRI Therapy: A New Paradigm

A new paradigm in cancer chemotherapy derives from the interaction between chemotherapeutics, including irinotecan and 5-fluorouracil (5-FU), and the immune system. The patient’s immune response can modulate chemotherapy effectiveness, and, on the other hand, chemotherapeutic agents can foster tumor...

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Bibliographic Details
Main Authors: Elena De Mattia, Jerry Polesel, Rossana Roncato, Adrien Labriet, Alessia Bignucolo, Sara Gagno, Angela Buonadonna, Mario D’Andrea, Eric Lévesque, Derek Jonker, Félix Couture, Chantal Guillemette, Erika Cecchin, Giuseppe Toffoli
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
IL15RA
SMAD3
survival
FOLFIRI
colorectal cancer
immune system
Online Access:https://www.mdpi.com/2072-6694/13/7/1705

Internet

https://www.mdpi.com/2072-6694/13/7/1705

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