Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma

Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma

TWIST1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial‐to‐mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion, and self‐renewal in glioblastoma (GBM) cells. However, the potential therapeutic relevance of TW has not been established throug...

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Bibliographic Details
Main Authors: Andrei M. Mikheev, Svetlana A. Mikheeva, Liza J. Severs, Cory C. Funk, Lei Huang, José L. McFaline‐Figueroa, Jeanette Schwensen, Cole Trapnell, Nathan D. Price, Stephen Wong, Robert C. Rostomily
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:Molecular Oncology
Subjects:
AKT
glioblastoma
glioma stem cells
periostin
tumorigenicity
TWIST1
Online Access:https://doi.org/10.1002/1878-0261.12320

Internet

https://doi.org/10.1002/1878-0261.12320

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