IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors

IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors

Macrophages in the tumor microenvironment respond to complex cytokine signals. How these responses shape the phenotype of tumor-associated macrophages (TAMs) is incompletely understood. Here we explored how cytokines of the tumor milieu, interleukin (IL)-6 and IL-4, interact to influence target gene...

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Bibliographic Details
Main Authors: Sahil Gupta, Arpit Jain, Shahzad Nawaz Syed, Ryan G. Snodgrass, Beatrice Pflüger-Müller, Matthias S. Leisegang, Andreas Weigert, Ralf P. Brandes, Ingo Ebersberger, Bernhard Brüne, Dmitry Namgaladze
Format: Article
Language:English
Published: Taylor & Francis Group 2018-10-01
Series:OncoImmunology
Subjects:
primary human monocyte derived macrophages (hmdms)
interleukins
rna sequencing
signal transducer and activator of transcription (stat)
basic leucine zipper atf-like transcription factor (batf)
crispr interference (crispri)
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1494110

Internet

http://dx.doi.org/10.1080/2162402X.2018.1494110

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