Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver.

Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver.

<h4>Objective</h4>Gremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 diabetes (T2D). We here examined...

Full description

Bibliographic Details
Main Authors: Roxana Khatib Shahidi, Jenny M Hoffmann, Shahram Hedjazifar, Laurianne Bonnet, Ritesh K Baboota, Stephanie Heasman, Christopher Church, Ivet Elias, Fatima Bosch, Jeremie Boucher, Ann Hammarstedt, Ulf Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0247300

Internet

https://doi.org/10.1371/journal.pone.0247300

Similar Items