Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Suppresses HIV Infection in Humanized Mice

Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Suppresses HIV Infection in Humanized Mice

Summary: Plasmacytoid dendritic cells (plasmacytoid DC, pDC) are major IFN-I producers and have been shown to be affected by HIV through ill-defined mechanisms. In this study, we directly assess the role of pDC in early infection, evaluating whether modulating their abundance can alter viral replica...

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Bibliographic Details
Main Authors: Tram N.Q. Pham, Oussama Meziane, Mohammad Alam Miah, Olga Volodina, Chloé Colas, Kathie Béland, Yuanyi Li, Frédéric Dallaire, Tibor Keler, Jean V. Guimond, Sylvie Lesage, Cheolho Cheong, Élie Haddad, Éric A. Cohen
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719314160

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http://www.sciencedirect.com/science/article/pii/S2211124719314160

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