Pore mutation N617D in the skeletal muscle DHPR blocks Ca2+ influx due to atypical high-affinity Ca2+ binding

Pore mutation N617D in the skeletal muscle DHPR blocks Ca2+ influx due to atypical high-affinity Ca2+ binding

Skeletal muscle excitation-contraction (EC) coupling roots in Ca2+-influx-independent inter-channel signaling between the sarcolemmal dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR1) in the sarcoplasmic reticulum. Although DHPR Ca2+ influx is irrelevant for EC coupling, its putative...

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Bibliographic Details
Main Authors: Anamika Dayal, Monica L Fernández-Quintero, Klaus R Liedl, Manfred Grabner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
voltage-gated ca2+ channel
non-conducting dhpr
ca2+ permeation
ca2+ selectivity
pore binding affinity
skeletal muscle excitation-contraction coupling
Online Access:https://elifesciences.org/articles/63435

Internet

https://elifesciences.org/articles/63435

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